Fusion Supplements AndroTest – Cyclo 4-AD

What is AndroTest

Androtest is the newest prohormone launch by Fusion Supplements.  While I don’t get particularly excited over clones of pre-existing prohormones this one is a bit more unique.  First, as I understand it, this is primarily a United Kingdom based company.  That is also the reason they are claiming this is the prohormone known as 4-androstenediol.  In the United States it is illegal to sell, and obtain.

ergo-cyclo-diolNow if you are a younger guy this may not mean much, but 4-Androstenediol was originally created by Patrick Arnold and sold under Ergopharm.  That product was called Cyclo-Diol SR and contained 125 mg’s of hydroxypropyl-beta cyclodextrin per tablet in 120 tablets.  The hormone itself converts directly into testosterone.

The idea with cyclodextrin based products is that they are complexed in a condom like structure which makes them water soluble.  And they are in general designed to be taken sublingually (placed under the tongue to dissolve).  This allows them to bypass first pass metabolism (liver breakdown).

Cyclo 4-AD is it better than the existing 4-AD Prohormones?

There is actually no definitive answer to this question.  But to give you an idea these hormones are typically converted in these pathways:

  • Cyclo 4-AD (4-androstenediol) converts directly to testosterone
  • 4-Androsterone (or 1-DHEA) converts to 4-androstenedione and 4-androstenediol, which both then convert to testosterone

This is why “diols” are often referred to as 1 step prohormones, and why the newest generation of prohormones like 1-Andro, 4-DHEA, and Decavol are considered two step prohormones.  The logic has always been that 1 step prohormones work better.  This may be true but I am not aware of any research that directly compares the two.  We know that two-step prohormones like 1-Androsterone work very well – New 1-Andro Study.

Research on Cyclo 4-AD

In 2002 a paper published in the Journal of Applied Physiology [Ref 1] measured the testosterone levels in strength training young men who took 1 dose of a cyclodextrin complex of 4-androstenediol.  The particular product used in this case contained 21.4 mg’s of 4-androstenediol, and 3.7 mg’s of androstenedione in a product (that no longer exists) called Kaizen Cyclo-Diol.  In other words the response you can see in the below tables should be similar to what you might experience with Fusion AndroTest.  Here’s a look at total and free testosterone levels:

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You can see in the tables after 60 minutes there were significant increases in serum testosterone levels.  When you translate the total testosterone peak of about 50 nmol/L you will find that it reached what we would call supraphysiological levels of around 1441 ng/dL testosterone levels.

You will also notice that testosterone levels fall almost all the way back down to baseline levels after just 3 hours.  This is the one problem with sublinguals.  They need to be dosed frequently to maintain testosterone levels.  In fact, an approved method of TRT is a drug known as Striant, which is basically a sublingual tablet but it’s placed in the upper lip to slow down it’s absorption into your bloodstream.

Is Androtest Legit?

As you can see by the research this is likely a good “test base” option for those interested in a prohormone that converts to testosterone in the UK.  The only cautions I have with this product are as follows:

  1. Fusion Supplements lists the compound on the label as “Cyclo 4-AD”, which technically could mean a lot of things.  It would be better if they had listed it as HBCD 4-Androstenediol.  They claim that is what is it on the forums.  I guess we will have to take their word for it.
  2. Fusion Supplements has not told us how much 4-Androstenediol is in each complexed tablet.  It’s likely 25mg’s, but it much less for all we know at the consumer level.

If you are a UK prohormone user interested in this product, I suggest you take the time to read some reviews on the rest of the Fusion Supplements product line.  This is really the first unique product they have launched so many of us will be interested to see how well it works.

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